Selected Publications
Hausrat TJ, Janiesch PC, Breiden P, Lutz D, Hoffmeister-Ullerich S, Hermans-Borgmeyer I, Failla AV, Kneussel M
Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice
Nature Communications (2022) 13, 4192
Muhia M, YuanXiang P, Sedlacik J, Schwarz JR, Heisler FF, Gromova KV, Thies E, Breiden P, Pechmann Y, Kreutz MR, Kneussel M
Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes
Communications Biology (2022) 5, 589
Radwitz J, Hausrat TJ, Heisler FF, Janiesch PC, Pechmann Y, Rübhausen M, Kneussel M
Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport
Cellular and Molecular Life Sciences (2022) 79(11):575
Lamothe-Molina PJ, Franzelin A, Beck L, Li D, Auksutat L, Fieblinger T, Laprell L, Alhbeck J, Gee CE, Kneussel M, Engel AK, Hilgetag CC, Morellini F, Oertner TG
ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning
Nature Communications (2022) 13: 6376
Brachet A, Lario A, Fernández-Rodrigo A, Heisler FF, Gutiérrez Y, Lobo C, Kneussel M, Esteban JA
A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression
Cell Reports (2021) 36(5):109499
Kneussel M, Sánchez-Rodríguez N, Mischak M, Heisler FF
Dynein and muskelin control myosin VI delivery towards the neuronal nucleus
iScience (2021) 24, 102416
Kneussel M, Friese MA
SnapShot: Neuronal dysfunction in inflammation
Neuron (2021) 109: 1754-1754e1
Lopes A, Hausrat T, Heisler F, Gromova K, Lombino F, Fischer T, Ruschkies L, Breiden P, Thies E, Hermans-Borgmeyer I, Schweizer M, Schwarz J, Lohr C, Kneussel M
Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits
PLoS Biology (2020) 18, e3000820.
Andres-Alonso M, Ammar MR, Butnaru I, Gomes GM, Acuña Sanhueza G, Raman R, Yuanxiang P, Borgmeyer M, Lopez-Rojas J, Raza SA, Brice N, Hausrat TJ, Macharadze T, Diaz-Gonzalez S, Carlton M, Failla AV, Stork O, Schweizer M, Gundelfinger ED, Kneussel M, Spilker C, Karpova A, Kreutz MR
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
Nature Communications (2019) 10(1):5448
Wagner W, Lippmann K, Heisler FF, Gromova KV, Lombino FL, Roesler MK, Pechmann Y, Hornig S, Schweizer M, Polo S, Schwarz JR, Eilers J, Kneussel M
Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Cell Reports (2019) 28, 11-20.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, Schindelin H
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Neuron. (2019) 101, 673-689.e11
Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M
Muskelin Coordinates PrPc Lysosome versus Exosome Targeting and Impacts Prion Disease Progression
Neuron (2018) 99(6):1155-1169.e9
Gromova KV, Muhia M, Rothammer N, Gee CE, Thies E, Schaefer I, Kress S, Kilimann MW, Shevchuk O, Oertner TG, Kneussel M.
Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.
Cell Reports (2018) 23, 2705-2717.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission
Nature Chemical Biology (2017) 13(2):153-160
Ghiretti AE, Thies E, Tokito MK, Lin T, Ostap EM, Kneussel M, Holzbaur ELF
Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B
Neuron (2016) 92(4):857-872
Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T
Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination
Neuron (2016) 92(4):845-856
Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J
Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling
Neuron (2016) 92(1):126-142
Muhia M, Thies E, Labonté D, Ghiretti AE, Gromova KV, Xompero F, Lappe-Siefke C, Hermans-Borgmeyer I, Kuhl D, Schweizer M, Ohana O, Schwarz JR, Holzbaur ELF, Kneussel M
The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory
Cell Reports (2016) 15(5):968-977
Kneussel M, Hausrat TJ
Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation
Trends in Neuroscience (2016) 39(3):170-182
Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, TG Smart, Triller A, Kneussel M
Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory
Nature Communications (2015) 6:6872
Maric HM, Kasaragod VB, Hausrat TJ, Kneussel M, Tretter V, Strømgaard K, Schindelin H
Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin
Nature Communications (2014) 5:5767
Kneussel M, Triller A, Choquet D
SnapShot: Receptor Dynamics at Plastic Synapses
Cell (2014) 157(7):1738-1738.e1
Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, Kneussel M, Barberis A
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP
Nature Communications (2014) 5:3921.
Heisler FF, Lee HK, Gromova KV, Pechmann Y, Schurek B, Ruschkies L, Schroeder M, Schweizer M, Kneussel M
GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites
PNAS (2014) 111(13):5030-5
Kneussel M, Wagner W
Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics
Nature Reviews Neuroscience (2013) 14(4):233-47
Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis
Nature Medicine (2012) 18(12):1805-11
Heisler FF, Loebrich S, Pechmann Y, Maier N, Zivkovic AR, Tokito M, Hausrat TJ, Schweizer M, Bähring R, Holzbaur ELF, Schmitz D, Kneussel M
Muskelin Regulates Actin Filament- and Microtubule-Based GABAA Receptor Transport in Neurons
Neuron (2011) 70(1):66-81
Janke C, Kneussel M
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton
Trends in Neurosciences (2010) 33(8):362-72
Maas C, Belgardt D, Lee HK, Heisler FF, Lappe-Siefke C, Magiera MM, van Dijk J, Hausrat TJ, Janke C, Kneussel M
Synaptic activation modifies microtubules underlying transport of postsynaptic cargo
PNAS (2009) 106(21):8731-6