Publications

Jürgen R Schwarz, Sandra Freitag , Yvonne Pechmann , Irm Hermans-Borgmeyer , Wolfgang Wagner , Sönke Hornig , Matthias Kneussel

Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go-related gene) K+ channel subunits

Science Advances (2024) 10:eadn6836

Henis M, Rücker T, Scharrenberg R, Richter M, Baltussen L, Hong S, Meka DP, Schwanke B, Neelagandan N, Daaboul D, Murtaza N, Krisp C, Harder S, Schlüter H, Kneussel M, Hermans-Borgmeyer I, de Wit J, Singh KK, Duncan KE, de Anda FC.

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation.

Science Advances (2024)10:eadf7001

Center for Molecular Neurobiology Hamburg, ZMNH: an overview

Ho KH, Candat A, Scarpetta V, Faucourt M, Weill S, Salio C, D'Este E, Meschkat M, Wurm CA, Kneussel M, Janke C, Magiera MM, Genovesio A, Meunier A, Sassoè-Pognetto M, Brill MS, Spassky N, Patrizi A.

Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.

Developmental Cell (2023), 58:2641-2651.

Gromova KV, Thies E, Janiesch PC, Lützenkirchen FP, Zhu Y, Stajano D, Dürst CD, Schweizer M, Konietzny A, Mikhaylova M, Gee CE, Kneussel M.

The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling.

Cell Reports (2023), 42:112743

Hausrat TJ, Janiesch PC, Breiden P, Lutz D, Hoffmeister-Ullerich S, Hermans-Borgmeyer I, Failla AV, Kneussel M

Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice

Nature Communications (2022) 13, 4192

Muhia M, YuanXiang P, Sedlacik J, Schwarz JR, Heisler FF, Gromova KV, Thies E, Breiden P, Pechmann Y, Kreutz MR, Kneussel M

Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes

Communications Biology (2022) 5, 589

Radwitz J, Hausrat TJ, Heisler FF, Janiesch PC, Pechmann Y, Rübhausen M, Kneussel M

Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport

Cellular and Molecular Life Sciences (2022) 79(11):575

Lamothe-Molina PJ, Franzelin A, Beck L, Li D, Auksutat L, Fieblinger T, Laprell L, Alhbeck J, Gee CE, Kneussel M, Engel AK, Hilgetag CC, Morellini F, Oertner TG

ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning

Nature Communications (2022) 13: 6376

Brachet A, Lario A, Fernández-Rodrigo A, Heisler FF, Gutiérrez Y, Lobo C, Kneussel M, Esteban JA

A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression

Cell Reports (2021) 36(5):109499

Kneussel M, Sánchez-Rodríguez N, Mischak M, Heisler FF

Dynein and muskelin control myosin VI delivery towards the neuronal nucleus

iScience (2021) 24, 102416

Kneussel M, Friese MA

SnapShot: Neuronal dysfunction in inflammation

Neuron (2021) 109: 1754-1754e1

Lopes A, Hausrat T, Heisler F, Gromova K, Lombino F, Fischer T, Ruschkies L, Breiden P, Thies E, Hermans-Borgmeyer I, Schweizer M, Schwarz J, Lohr C, Kneussel M

Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits

PLoS Biology (2020) 18, e3000820.

Andres-Alonso M, Ammar MR, Butnaru I, Gomes GM, Acuña Sanhueza G, Raman R, Yuanxiang P, Borgmeyer M, Lopez-Rojas J, Raza SA, Brice N, Hausrat TJ, Macharadze T, Diaz-Gonzalez S, Carlton M, Failla AV, Stork O, Schweizer M, Gundelfinger ED, Kneussel M, Spilker C, Karpova A, Kreutz MR

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals

Nature Communications (2019) 10(1):5448

Wagner W, Lippmann K, Heisler FF, Gromova KV, Lombino FL, Roesler MK, Pechmann Y, Hornig S, Schweizer M, Polo S, Schwarz JR, Eilers J, Kneussel M

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.

Cell Reports (2019) 28, 11-20.

Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, Schindelin H

Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.

Neuron. (2019) 101, 673-689.e11

Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M

Muskelin Coordinates PrPc Lysosome versus Exosome Targeting and Impacts Prion Disease Progression

Neuron (2018) 99(6):1155-1169.e9

Gromova KV, Muhia M, Rothammer N, Gee CE, Thies E, Schaefer I, Kress S, Kilimann MW, Shevchuk O, Oertner TG, Kneussel M.

Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.

Cell Reports (2018) 23, 2705-2717.

Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

Nature Chemical Biology (2017) 13(2):153-160

Ghiretti AE, Thies E, Tokito MK, Lin T, Ostap EM, Kneussel M, Holzbaur ELF

Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B

Neuron (2016) 92(4):857-872

Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

Neuron (2016) 92(4):845-856

Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J

Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling

Neuron (2016) 92(1):126-142

Muhia M, Thies E, Labonté D, Ghiretti AE, Gromova KV, Xompero F, Lappe-Siefke C, Hermans-Borgmeyer I, Kuhl D, Schweizer M, Ohana O, Schwarz JR, Holzbaur ELF, Kneussel M

The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory

Cell Reports (2016) 15(5):968-977

Kneussel M, Hausrat TJ

Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation

Trends in Neuroscience (2016) 39(3):170-182

Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, TG Smart, Triller A, Kneussel M

Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory

Nature Communications (2015) 6:6872

Maric HM, Kasaragod VB, Hausrat TJ, Kneussel M, Tretter V, Strømgaard K, Schindelin H

Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin

Nature Communications (2014) 5:5767

Kneussel M, Triller A, Choquet D

SnapShot: Receptor Dynamics at Plastic Synapses

Cell (2014) 157(7):1738-1738.e1

Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, Kneussel M, Barberis A

Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP

Nature Communications (2014) 5:3921.

Heisler FF, Lee HK, Gromova KV, Pechmann Y, Schurek B, Ruschkies L, Schroeder M, Schweizer M, Kneussel M

GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites

PNAS (2014) 111(13):5030-5

Kneussel M, Wagner W

Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics

Nature Reviews Neuroscience (2013) 14(4):233-47

Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

Nature Medicine (2012) 18(12):1805-11

Heisler FF, Loebrich S, Pechmann Y, Maier N, Zivkovic AR, Tokito M, Hausrat TJ, Schweizer M, Bähring R, Holzbaur ELF, Schmitz D, Kneussel M

Muskelin Regulates Actin Filament- and Microtubule-Based GABAA Receptor Transport in Neurons

Neuron (2011) 70(1):66-81

Janke C, Kneussel M

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton

Trends in Neurosciences (2010) 33(8):362-72

Maas C, Belgardt D, Lee HK, Heisler FF, Lappe-Siefke C, Magiera MM, van Dijk J, Hausrat TJ, Janke C, Kneussel M

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

PNAS (2009) 106(21):8731-6

Selected Publications