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Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
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The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory
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Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics.
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Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation.
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GRIP1 interlinks N-Cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites.
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Muskelin regulates actin filament- and microtubule-based GABAA receptor transport in neurons.
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Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
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Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K.
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Nat Chem Biol. (2017) 13, 153-160.


Ghiretti AE, Thies E, Tokito MK, Lin T, Ostap EM, Kneussel M, Holzbaur EL.
Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B.
Neuron. (2016) 92, 857-872


Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T.
Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.
Neuron. (2016) 92, 845-856.


Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J.
Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.
Neuron. (2016) 92, 126-142.


Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, Smart TG, Triller A, Kneussel M.
Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
Nature Communications (2015) 6:6872.


Delto CF, Heisler FF, Kuper J, Sander B, Kneussel M, Schindelin H.
The LisH Motif of Muskelin Is Crucial for Oligomerization and Governs Intracellular Localization.
Structure (2015) 23, 364-373.


Maric HM, Kasaragod VB, Hausrat TJ, Kneussel M, Tretter V, Strømgaard K, Schindelin H.
Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin.
Nature Communications (2014) 5: 5767.


Kneussel M, Triller A, Choquet D.
SnapShot: receptor dynamics at plastic synapses.
Cell (2014), 157, 1738-1739.


Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, Kneussel M, Barberis A.
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
Nature Communications(2014) 5: 3921.


Heisler FF*, Lee HK*, Gromova KV, Pechmann Y, Schurek B, Ruschkies L, Schroeder M, Schweizer M, Kneussel M.
GRIP1 interlinks N-Cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites.
Proc. Natl. Acad. Sci. USA (2014), 111, 5030-5035.


Kneussel M, Wagner W.
Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics.
Nature Reviews Neuroscience (2013), 14, 233-247.


Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA.
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.
Nature Medicine (2012), 18, 1805-1811.


Heisler FF, Loebrich S, Pechmann Y, Maier N, Zivkovic AR, Tokito M, Hausrat TJ, Schweizer M, Bähring R, Holzbaur EL, Schmitz D, Kneussel M.
Muskelin regulates actin filament- and microtubule-based GABAA receptor transport in neurons.
Neuron. (2011) 70, 66-81.


Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, Schwarz JR, Holzbaur EL, Kneussel M.
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Journal of Neuroscience (2010) 30, 12733-12744.


Janke C, Kneussel M.
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton.
Trends in Neurosciences (2010) 33, 362-72


Lappe-Siefke C, Loebrich S, Hevers W, Waidmann OB, Schweizer M, Fehr S, Fritschy JM, Dikic I, Eilers J, Wilson SM, Kneussel M.
The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice.
PLoS Genetics (2009) 5, e1000631.


Maas C, Belgardt D, Lee HK, Heisler FF, Lappe-Siefke C, Magiera MM, van Dijk J, Hausrat TJ, Janke C, Kneussel M.
Synaptic activation modifies microtubules underlying transport of postsynaptic cargo.
Proc Natl Acad Sci U S A. (2009) 106, 8731-8736.


Loebrich S, Bähring R, Katsuno T, Tsukita S, Kneussel M.
Activated radixin is essential for GABAA receptor alpha5 subunit anchoring at the actin cytoskeleton.
EMBO Journal (2006) 25, 987-999.


Maas C, Tagnaouti N, Loebrich S, Behrend B, Lappe-Siefke C, Kneussel M.
Neuronal cotransport of glycine receptor and the scaffold protein gephyrin.
Journal of Cell Biology (2006) 172, 441-451


Kneussel M.
Postsynaptic scaffold proteins at non-synaptic sites. The role of postsynaptic scaffold proteins in motor-protein-receptor complexes.
EMBO Reports (2005) 6, 22-27.


Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz H, Kneussel M.
Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes.
Journal of Neuroscience (2002) 22, 5393-5402.


Kneussel M, Brandstätter JH, Gasnier B, Feng G, Sanes JR, Betz H.
Gephyrin-independent clustering of postsynaptic GABAA receptor subtypes.

Molecular and Cellular Neuroscience (2001) 17, 973-982.


Kneussel M, Betz H.
Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model.
Trends in Neurosciences (2000) 23, 429-35.


Kneussel M, Haverkamp S, Fuhrmann JC, Wang H, Wässle H, Olsen RW, Betz H.
The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse.
Proc Natl Acad Sci U S A. (2000) 97, 8594-8599.


Kneussel M, Brandstätter JH, Laube B, Stahl S, Müller U, Betz H.
Loss of postsynaptic GABAA receptor clustering in gephyrin-deficient mice.
Journal of Neuroscience (1999) 19, 9289-9297.


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